Much Ado About Squalene

In July, Dr. Mercola's* article on squalene in the H1N1 vaccines was posted at Prison Planet. Since then, info from this article has found its way into many of the fear-mongering articles on the H1N1 vaccine, and of course into online comments (including a few left on this very blog by the Arbiter of All Online Knowledge, Anonymous). I'm not referring, here, to reasoned and informed articles about the real risks associated with flu vaccines. I'm referring to ridiculous alerts churned out by naturopaths and paranoids, usually written in ALL CAPS. Sadly, these kinds of paranoia-pandering articles on H1N1 vaccine are a lot easier to find than science-based articles on the subject.

Squalene is a naturally-occurring oil already present in the human body. It's squalene that leaves fingerprints behind when you touch a surface. It's also found in olive oil. According to Dr. Mercola, however, injecting squalene into the human body (as opposed to digesting it) is hazardous. He contends that injected squalene causes the immune system to attack all squalene in the body, compromising the nervous system. To date, I have not found any scientific research that supports this. If you know of any, by all means let me know. The results from a 2000 study, published in The American Journal of Pathology, indicated that when rats were injected with squalene, they experienced "chronic, immune -mediated joint specific inflammation" (arthritis).

The second-biggest problem with using this study to support anti-adjuvant criticism (the biggest problem can be found at the bottom of this post) is that rodent pathogenesis does not necessarily have any relationship to human pathogenesis. Though we share a lot of DNA, rats are not human and humans are not rats (well, most of the time, anyway). When it comes to adverse reactions to human vaccination, epidemiological studies are of far more value than lab studies involving animals.
This issue has cropped up in anti-vaccine fearmongering before. In 2003, Dr. Mady Hornig seemed to confirm parents' worst fears when he announced that rats suffering autoimmune disorders, when injected with thimerosal (a vaccine preservative containing mercury), displayed autism-like symptoms.
This was a deeply flawed study on several counts (for one thing, autistic humans don't necessarily have autoimmune disorders, so selecting only rats with these disorders was a strange choice indeed). But the biggest problem, again, is that rodent pathogenesis may have no relationship to human pathogenesis.

Other concerns:

Dr. Mercola, Generation Rescue, and other vaccine opponents state that squalene in vaccine adjuvants may have caused Gulf War Syndrome. Trace amounts of squalene were reportedly found in the anthrax vaccine, though this probably resulted from lab contamination rather than vaccine contamination.
Even if there was squalene in the vaccine for some reason, there is no evidence supporting a link between squalene and any of the symptoms reported by Gulf War I vets. The anthrax vaccine is frequently mentioned as a possible culprit, but the anthrax vaccine uses aluminum hydroxide, not squalene, as an adjuvant.
The Research Advisory Committee on Gulf War Veterans' Illnesses has concluded that Gulf War Syndrome exists and was probably caused not by vaccines, but by pyridostigmine bromide and perhaps pesticides.

This shrill and grammar-challenged essay claims that H1N1 vaccine contains a million times more squalene than the anthrax vaccine (which doesn't contain any).

Austrian journalist Jane Burgermeister contends that "clinical studies published by Baxter’s own scientific team that patented the H1N1 vaccine demonstrate that such adjuvants are, at best, useless." Though numerous studies have shown that they are effective, others (like this Baxter-funded study of the whole-cell Avian Flu vaccine, published last year in The New England Journal of Medicine) have shown that adjuvants did not enhance antibody response. So at this point, the bulk of the evidence is in favour of adjuvants.

This piece by activist Deborah Dupre claims the adjuvant developed by Dr. Jules Freund in the '50s (usually called Freund's complete adjuvant) contains squalene and was found by Freund himself to cause "terrible, incurable conditions" in test animals, including allergic aspermatogenesis, allergic encephalomyelitis, allergic neuritis, and other autoimmune disorders. But Freund's complete adjuvant is not approved for human use. It is found only in veterinary vaccines.
In other words: Freund's complete adjuvant has nothing to do with the H1N1 vaccine. At all.

More importantly: No human vaccine used in the U.S. contains squalene or any other form of oil-based adjuvant. Period. Squalene adjuvants are present in a small number of European vaccines, but the only adjuvant approved by the FDA is aluminum salts, which have been in use in U.S. vaccines since the 1930s.
Adjuvants will not be present in any of the H1N1 vaccine distributed in the U.S.
From the CDC's FAQ page on H1N1 vaccine: "According to current federal plans, only unadjuvanted vaccines will be used in the United States during the 2009 flu season. This includes all of the 2009 H1N1 and seasonal influenza vaccines that will be available for children and adults in both the injectable and nasal spray formulations... There is no plan at this time to recommend a 2009 H1N1 influenza vaccine with an adjuvant."

There's really nothing more to say about this.



*Though a trained and licensed MD, Mercola has become a Master of Woo. Serious woo. He advises fans never to eat grains. At all. Ever. He believes that microwave ovens actually change the chemical structure of food, rendering it "unrecognizable" to the human body. He teaches that bras cause breast cancer and should be avoided as much as possible, which sounds a wee bit self-serving to me (and is not supported by any medical evidence).

Bugging Out II: A Long Way to Go to Avoid a Shot

Remember the guy who's hiding out in the woods to escape flesh-eating robots and other scary stuff that doesn't actually exist? Well, it seems Alex Jones isn't averse to the idea of bugging out, either.
Despite all his talk about not fearing death at the hands of the elite scum who threaten him continuously, despite all his rhetoric about the Spirit of '76, despite his avowed uberpatriotism, Jones isn't above fleeing his country if the sh** gets too heavy. One of his guests today was Mike Adams the Health Ranger, an advertiser who fled the U.S. for Ecuador. He and fellow expats were concerned about the H1N1 vaccine, the food supply, the economy, and U.S. fascism. So, he moved to a country plagued by poverty, disease, and kidnapping, without clean drinking water. Good thinkin', Mike. You'll be safe there.

Jones said he, too, has looked around for places to flee with his family.

Here are Mike Adam's "10 Swine Flu Lies Told by the Mainstream Media":

1. There are no adjuvants in H1N1 vaccine.
This is quite tricky of Mr. Adams. You see, there are adjuvants in H1N1 vaccine. But not in the doses being distributed in the U.S. So by saying "there are adjuvants in the vaccine!", you're not exactly being dishonest, because European countries have been using WHO-approved adjuvants like squalene for years - with good results.
Incidentally, I couldn't find any support for Adams' contention that squalene causes infertility. I'll be posting on squalene soon, since it has become one of the biggest boogeymen in the H1N1 vaccine hysteria propagated by Jones & Co.

2. Swine Flu is more dangerous than seasonal flu.
I've had both this year. The Swine Flu was worse, and if I had a pre-existing health problem like asthma, I might have been one of the many people confined to hospital and placed on oxygen because of H1N1. While it's true that seasonal flus result in approximately 20,000 U.S. deaths per year, H1N1 is severely affecting young people that the seasonal flus barely bother. It's not the Black Death, but it's serious stuff.

3. Vaccines protect you from Swine Flu.
Yes, Mr. Adams, the purpose of the H1N1 vaccine is to prevent H1N1. Will it work? We don't know. But inoculation is a better bet than crossing your fingers and glugging colloidal silver until you turn blue.

4. Vaccines are safe.
For the most part, they are. While Adams insists that no one has proven they're safe, he doesn't mention that no one has proven they're not.

5. The vaccine isn't mandatory.
For the average American, it isn't. But health workers and some teachers are being asked to take the shot for the safety of their charges, and their refusal could put those people entrusted to their care at risk.

6. Getting a vaccine is a good bet on your health.
Usually. It's a better bet than standing in the sun without sunscreen because sunscreen causes cancer, cutting your open wounds in lieu of getting tetanus shots, avoiding fluoride because you think it will render you sterile, or any of the other ludicrous health measures Jones has recommended.

7. The vaccine isn't made with weakened live virus.
This is just flat-out wrong. I know of no mainstream media outlet that claims flu vaccines aren't made with weakened live virus, because that is how they're made and everyone with any knowledge of vaccination knows it. The vaccine wouldn't be effective otherwise. It's nothing to be scared of.

8. Washing your hands will help you avoid exposure.
Again, Mr. Adams is being tricky here. No one is saying that hand-washing reduces exposure; it reduces transmission.

9. Children are more vulnerable to Swine Flu than adults.
Generally, children are more susceptible to flus and other infectious disease than adults. It's not a lie. Anyone with a kindergarten-age child knows that if there's something going around, your child stands a really good chance of catching it and bringing it home to the rest of the family.

10. There is nothing else you can do beyond a vaccine and Tamiflu.
Again, nobody in mainstream media is saying this. Adams already mentioned hand-washing, so what the hell is he trying to pull, here? No one denies that good old-fashioned immunity-boosting and prevention are wise, and news stories have been chock-full of advice on how to stay healthy by exercising, taking vitamins if necessary, eating properly, etc.